Factor VIIa Inhibitor - References
Posters & Presentations
- Ramanathan RK, Gressler V, et al. Phase I/II study of PCI-27483, a coagulation Factor VIIa (FVIIa) inhibitor, in advanced pancreatic cancer patients receiving treatment with gemcitabine. [Poster Presentation] American Society of Clinical Oncology Gastrointestinal Cancers Symposium, San Francisco, CA, 20-22 January, 2011
- Holsinger LJ, Young WB et al. Small molecule-mediated inhibition of Factor VIIa catalytic activity blocks fVIIa:TF cellular signaling and chemokine secretion in human tumor cell lines [abstract]. In: Proceedings of the 97th Annual Meeting of the American Association for Cancer Research, Washington, DC, 1-5 April 2006.
- Loury DJ, Buggy J et al. PCI-27483, a small molecule inhibitor of Factor VIIa, inhibits growth of BxPC3 pancreatic adenocarcinoma xenograft tumors [abstract]. In: Proceedings of the 99th Annual Meeting of the American Association for Cancer Research, San Diego, CA, 12-16 April 2008.
Scientific Manuscripts
- Khorana A, Ahrendt S, Ryan C, et al. Tissue factor expression, angiogenesis, and thrombosis in pancreatic cancer. Clin Cancer Res. May 2007;13(10):2870-2875.
- Khorana A, Francis C, Culakova E, Fisher R, Kuderer N, Lyman G. Thromboembolism in hospitalized neutropenic cancer patients. J Clin Oncol. Jan 2006;24(3):484-490.
- Klerk C, Smorenburg S, Otten H, et al. The effect of low molecular weight heparin on survival in patients with advanced malignancy. J Clin Oncol. Apr 2005;23(10):2130-2135.
- Levine M. Managing thromboembolic disease in the cancer patient: efficacy and safety of antithrombotic treatment options in patients with cancer. Cancer Treat Rev. Jun 2002;28(3):145-149.
- Rickles F, Patierno S, Fernandez P. Tissue factor, thrombin, and cancer. Chest. Sep 2003;124(3 Suppl):58S-68S
- Schaffner F, Ruf W. Tissue factor and protease-activated receptor signaling in cancer. Semin Thromb Hemost. Mar 2008;34(2):147-153.
- Young W, Mordenti J, Torkelson S, et al. Factor VIIa inhibitors: chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model. Bioorg Med Chem Lett. Apr 2006;16(7):2037-2041.
